Each wound on a given horse was randomly assigned to 1 of 4 treatment groups (SSC, TAO, HNE, or no topical treatment ). Wounds were inoculated with bacteria and fungi the next day. PROCEDURES A 2.5 × 2.5-cm, full-thickness, cutaneous wound was created at the dorsal aspect of each metacarpus and metatarsus (1 wound/limb/horse), covered with nonadhesive dressing, and bandaged. OBJECTIVE To determine the effects of 3 topically applied treatments (1% silver sulfadiazine cream, triple antimicrobial ointment, and hyperosmolar nanoemulsion ) on microbial counts, exuberant granulation tissue (EGT) development, and reepithelialization of contaminated wounds at the distal aspect of the limbs of horses. The images shown were obtained on days 1 (A, E, I, and M), 7 (B, F, J, and N), 19 (C, G, K, and O), and 45 (D, H, L, and P). Bandage changes continued at predetermined intervals until day 45 photographs were obtained at each bandage change and at predetermined intervals afterward until evaluation of wound healing was completed (day 135). Treatments were applied during bandage changes according to a predetermined schedule from day 2 until day 21. Each wound on a given horse was assigned to a treatment group by random selection from a hat however, assignments were constrained so that each limb (eg, the 8 left forelimbs) was assigned to each treatment twice. On day 1, all wounds were contaminated by application of a filter paper inoculated with a combination of Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Candida albicans. On day 0 for each horse (n = 8), a wound was created over each metacarpus and metatarsus, covered with a nonadherent dressing, and bandaged. Representative photographs depicting healing of surgically created wounds at the distal aspect of the left forelimb in horses treated topically with HNE (A to D), TAO (E to H), 1% SSC (I to L), or no medication (control M to P).

Silver sulfadiazine cream 1